Microtubules motors and movement
Introduction: Microtubules are responsible for different kinds of cell movements including the intracellular transport and positioning of membrane vesicles and organelles, the separation of chromosomes at mitosis and the beating of cilia and flagella .Motor protein's action and the polymerization and depolarization of microtubules use the energy from ATP hydrolysis to regulate the movement and force .
There are two large families of motor protein which mainly responsible for powering of movements where the microtubules participate.
Kinesin 1 motor protein and Dynein : There are two major class of motor protein associated with movement along microtubules.
1.kinesin 1:This is a protein belonging to class of motor protein found in eukaryotes.
Kinesin 1 was firstly discovered kinesin.
Kinesin is like a vehicle which move along the microtubules filament by hydrolysis of ATP ,has some cellular functions like mitosis, meiosis and transport of cellular cargo .Kinesin walks towards the plus end of microtubules .The cargo and membrane components are transported from the centre of cell towards the periphery .The type of the transport is known as Anterograde. Kinesin 1 can move along the single or parallel microtubules for a long distance at 0.8 μm/S .
2.Dynein : It is a family of cytoskeletal motor proteins that moves along microtubules towards the minus end and this types of transport is opposite to the kinesin ,called retrograde .It transports cellular cargo and converts the chemical energy stored in ATP to mechanical work .Dynein consist of two or three heavy chains in association with multiple light and intermediate chains
It is a large complex molecule at least 1.2 MDa. It also generates sliding between ciliary doublet microtubules.
Thank you..
There are two large families of motor protein which mainly responsible for powering of movements where the microtubules participate.
Kinesin 1 motor protein and Dynein : There are two major class of motor protein associated with movement along microtubules.
1.kinesin 1:This is a protein belonging to class of motor protein found in eukaryotes.
Kinesin 1 was firstly discovered kinesin.
Kinesin is like a vehicle which move along the microtubules filament by hydrolysis of ATP ,has some cellular functions like mitosis, meiosis and transport of cellular cargo .Kinesin walks towards the plus end of microtubules .The cargo and membrane components are transported from the centre of cell towards the periphery .The type of the transport is known as Anterograde. Kinesin 1 can move along the single or parallel microtubules for a long distance at 0.8 μm/S .
2.Dynein : It is a family of cytoskeletal motor proteins that moves along microtubules towards the minus end and this types of transport is opposite to the kinesin ,called retrograde .It transports cellular cargo and converts the chemical energy stored in ATP to mechanical work .Dynein consist of two or three heavy chains in association with multiple light and intermediate chains
It is a large complex molecule at least 1.2 MDa. It also generates sliding between ciliary doublet microtubules.
Thank you..
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