Mechanism of Vesicles Docking and Fusion

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Abstract: Analysis of Biochemical and Genetics study reveal a molecular mechanism which is selectively cargo molecule transport between donor and target compartments .
                                       Different membrane proteins participate in vesicular fusion .
        #We will discuss about some membrane proteins which participate in vesicles docking and fusion .










Protein involved in vesicle docking


1: SNAREs protein: Complimentary sets of vesicles SNAREs(v-SNARE) and target membrane (t-SNARE) contribute to the selectivity of transport vesicle docking and fusion.

  v-SNARE: During the budding of transport vesicles it is packaged together with coat protein from donor membrane and then bind to complementary t-SNARE in target membrane.


  t-SNARE: After the fusion t-SNARE Mechanismand v-SNARE make tight complex 
  
Next this complex have to dissociate so that the  SNARE protein( v-SNARE) can be recycled to the donor compartment for do the same process again .










2:Rab proteins: The second important protein after SNARE is Rab .These are monomeric GTPase ;found in nearly every organelle at least one ,present in vesicle ,used for recognition of target membrane. Rab protein and it's effector help in vesicle dock and also facilitate the joining of v-SNARE and t-SNARE in proper way.











A hand made figure ,
      Pls see the whole procedure.


3: NSF protein: It bind to the SNARE complex via adaptor proteins.

 Hope u people understood the procedure ....I have given the basic idea on this topic .
   
  U could learn it in densely from many books that could easily shop able from market or online like flipkart or Amazon . 





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